Begin by just keeping the board fairly clear, i usually start with no creatures in my hand at all, just a bunch of kill spells and things like Despise / Distress. This is because most of the important creatures cost 4+ mana so you need to keep the board under control for as long as you can, this is also handy as it gives you many opportunities to Surgical Extraction some annoying cards because your opponent should be trying to make the most of you without any creatures and will start pumping threats.
Once you start drawing your big guys it just becomes an aggro game, any combination of creatures/weapons is a sure way to win. i.e.
-Phyrexian Obliterator + Lashwrithe / Batterskull / Phyrexian Metamorph
Sideboard explained (Still working on this):
3x Black Sun's Zenith: I'sve noticed a lot of decks recently taking advantage of exhalted, and a lot of human weenies as well. Side this in to keep clearing the field of 1 toughness creatures.
2x Murder: Sometimes you need some extra kill spells, or the Go for the Throat isnt helping at all with that wurmcoil your opponent keeps tutoring for, helps out a little bit.
1x surgical extration: Having 2 mainboard has shown to be just as effective as 3x in general matchups, versus things like delver and wolfrun you can side this in to help deal with the counterspells and creatures, which tend to come in full playsets in those decks
3x Geth's Verdict: To help get around hexproof creatures, ie Invisible Stalker / Geist of Saint Traft.
2x Hex Parasite: Plainswalker killer, plain and simple, also allows Geralf's Messenger another chance to return from the grave.
3x Nihil Spellbomb: Card draw, but more importantly is good against delver / zombie decks, just make sure you surgical anything you want beforehand.
2x Ghost Quarter: Just something to kill Inkmoth Nexus (not like we cant do that anyway) or Kessig Wolf Run.
1x Praetor's Grasp: Just needed another card for the sideboard and wanted to test this out, and it works well when cast. You can remove a bomb and if that bomb was a wurmcoil or something black then even better.