Lock up the charms in the Isochron Scepter to answer anything and lock out their wincons with Jester's Scepter and Circu, Dimir Lobotomist.

Aditionally, Surgical Extraction and Extirpate eliminate the possibility of them getting their wincons if Dimir Charm, Jester's Scepter, or Thoughtseize got them. Reap Intellect is a mid-late game finisher, basically removing all of their options and answers in hand, and destroying the opportunity of them drawing another copy

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