Rhadamanthus says... #2
To be clear: a response isn't just someone saying "I want to do something", it's actually doing something. If your opponent responds to your Disfigure by casting a spell from their hand then you can make another response to that spell, but you can't back up the game to somehow respond before they cast it.
September 19, 2019 12:54 p.m.
Now, if you suspect your opponent has a response, you do get priority first after your Disfigure goes on the stack and could cast something else in response to your own spell on the assumption your opponent has, say, a Counterspell or a Giant Growth or something like that.
You couldn't do it with Duress because it's not an instant, but if you had a Mardu Charm , for instance, you could try to pre-emptively get rid of your opponent's possible response before they use it (or reveal they even have one).
But as others have said, once your opponent actually responds with their spell, it's on the stack and you can't try to take it out of their hand with your spell.
September 19, 2019 3:11 p.m.
Rhadamanthus says... #5
@Lycasde: If your question has been answered, please use the green "Mark as Answer" button next to the response that best answered it so that this post can move out of the list of unanswered questions.
September 20, 2019 5:34 p.m.
In the future, please remember to hit the green “mark as answer” button to indicate your question has been resolved. Since since this question has been answered for a couple of days, I have gone ahead and marked an answer on your behalf.
Neotrup says... Accepted answer #1
Once your opponent casts their response, it's on the stack so you cannot make them discard it. There is no time that you know the card they are wanting to cast while it's still in their hand. Additionally, Duress is a sorcery so it cannot be cast in response to anything under normal circumstances. You could respond to their response with another Disfigure so that their creature dies before their response resolves.
September 19, 2019 9:45 a.m.