Karmic Guide + clones are a powerhouse in this deck. When you put out a
Karmic Guide you can reanimate all of your clones from of your graveyard, each copying
Karmic Guide. Then, you can flicker all of them using
Yorion, Sky Nomad and clone something else when they return to play. Make sure to flicker your guides out right before your turn though, otherwise you might end up sacrificing them to echo.
In a pinch, if you don't have a Charming Prince or Sakashima of a Thousand Faces, you can still play a second Yorion or another clone, you'll just lose one to the legend rule.
If you have a Yorion in play and then put a second Yorion and a Karmic Guide into play at the same time, one Yorion will be destroyed by the legend rule as a state based action before any enters-the-battlefield abilities are put onto the stack. As a result, you can destroy the NEW Yorion, exile both the old Yorion and the Karmic Guide, then reanimate the destroyed Yorion. You could do it another way, but this keeps Yorion out of your graveyard and safe from sorcery-speed graveyard removal.
If you have multiple flicker effects (like in the above example), consider splitting them up them rather than just exiling all of your creatures using a single Yorion. This can help against mass-removal if you do it right (Ideally, you'd put one group in play, exile some creatures including a Karmic Guide, then put the second group into play, and exile more creatures including a Karmic Guide). Having multiple flicker groups also lets you return to play anything you want to copy prior to your clones. Otherwise, you'd have to leave whatever you want to copy in play at all times (clones can't copy creatures entering the battlefield at the same time as they are).
If your clones would enter play and don't have anything to copy but you're putting a Karmic Guide into play at the same time, state-based actions will send your 0/0 clones to your discard pile before ETB abilities go on the stack. As a result, you can reanimate all of the clones, each copying Karmic Guide.
When you put a Karmic Guide and mill-cards into play at the same time, you have to choose all targets before milling anybody. This means you can't mill yourself, then reanimate something you just milled. But if you have another Karmic Guide or a clone in your graveyard when the first Karmic Guide enters play, you can work around this restriction. So, leaving some of these cards in your graveyard for future turns may be beneficial to you. Also note that clone effects are a "may". So, you can choose to copy nothing, sending them to your graveyard, then reanimate them (thanks to state based actions resolving before triggers are put on the stack).
In the late game, if you are getting low on cards but still want to dig something out of your deck, you can use Charming Princes to scry cards to the bottom of your deck.
In multiplayer games, if a player leaves the game during his or her turn, that turn continues to its completion without an active player (800.4g). This means there is still an end step in which your triggers happen.
Prefer to play Sakashima on turn 4 over the cheaper clones.
