Here I want to explain what Options you have for your Meta.
Ceremonious Rejection: One of your best answers vs Chalice of the Voide. While at the same time relevant over different matchups like Tron, Lantern, Eldrazi. The main problem is Cavern of Souls that can make this card dead vs Eldrazi.
Disdainful Stroke: Extremely potent card vs Tron. It also hits other combo pieces like Ad Nauseam and Scapeshift. This card is very good all decks that want to cast high cmc spells but dont play a Cavern of Souls.
Dispel: Good vs control decks and Spell based combo decks. Vs control helps you to resolve and protect your cards. Vs Combo, this includes Burn, this card can be an all-star.
Countersquall: Negate with upside. Good vs Combo and can be good vs Control if you board into a grindy gameplan game 2/3.
Dismember: For matchups where you need extra spot removal. Eldrazi is an example where it shines. Also Dismember allows you to make positive trades with bigger creatures without losing your guys.
Collective Brutality: Very versatile card. It shines in match ups like Burn. It is low curve creature removal, life gain + burn for reach and sustain and Duress. Even if not all mods are relevant it is still a good choice, as example vs Merfolk.
Liliana's Defeat: If you play vs a lot of other Shadow decks this might be a solid choice.
Geth's Verdict: If there is Bogels in your meta and you want to hate on the slippery boi.
Flaying Tendrils: This card can win you the game vs G/W/x value decks. If you have decks that build on Kitchen Finks and Voice of Resurgence this card should your number one choice. When this card is good it often a one-sided boardwhipe but can fall short vs decks that play lords and pump there beaters outside of the of -2/-2.
Damnation: best vs decks that use lords like merfolks but also hits you.
Illness in the Ranks: Very good vs decks that play Lingering Souls.
Night of Souls' Betrayal: Very good vs decks like Infect, Elves and decks that play Young Pyromancer and Linergins Souls.
Hostage Taker: Another good card in grindy games where creatures matter.
Liliana, the Last Hope: Removal, recursion and game ending Ultimate. She is perfect for games you need to grind.
Liliana of the Veil: Better in a Sideboard that does not board into a lot of counterspells. Very good vs decks that dont go wide on the board like Bogels or Shadow. Having this Lili and Jace on the board is an extremely potent combo.
Pithing Needle: Not only there to name Planeswalker like Karn Liberated. But also, here for cards like Azcanta, the Sunken Ruin.
Ratchet Bomb and Engineered Explosives : One of your only ways to kill Chalice of the Voide and Enchantments like Runed Halo. Both are good vs low curve aggro decks and tokens. Explosives is better vs aggro, because it is faster to use, and Bomb is better as removal from annoying permanents.
Surgical Extraction: Very good vs combo in combination with Discards and Counterspells, or decks where you care mostly about one card.
Nihil Spellbomb: Better vs all in Graveyard decks then Surgical or decks that use the Graveyard as a resource.